1. Academic Validation
  2. Design, Synthesis, Insecticidal Activity, and SAR of Aryl Isoxazoline Derivatives Containing Pyrazole-5-carboxamide Motif

Design, Synthesis, Insecticidal Activity, and SAR of Aryl Isoxazoline Derivatives Containing Pyrazole-5-carboxamide Motif

  • J Agric Food Chem. 2023 Oct 11;71(40):14458-14470. doi: 10.1021/acs.jafc.3c01608.
Liang-Kun Zhong 1 2 Xin-Peng Sun 1 Liang Han 1 Cheng-Xia Tan 1 Jian-Quan Weng 1 Tian-Ming Xu 2 Jian-Jun Shi 3 Xing-Hai Liu 1
Affiliations

Affiliations

  • 1 College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • 2 Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China.
  • 3 College of Chemistry & Chemical Engineering, Huangshan University, Huangshan 245041, China.
Abstract

It is important to develop new insecticides with a new mode of action because of increasing pesticide resistance. In this study, a series of novel aryl isoxazoline derivatives containing the pyrazole-5-carboxamide motif were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, and HRMS. Bioassays indicated that the 24 compounds synthesized possessed excellent insecticidal activity against Mythimna separate and no activity against Aphis craccivora and Tetranychus cinnabarinus. Among these aryl isoxazoline derivatives, 3-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydrozol-3-yl)-N-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxamide (IA-8) had the best insecticidal activity against M. separate, which is comparable with the positive control fluralaner. The molecular docking results of compound IA-8 and fluralaner with the GABA model demonstrated the same docking mode between compound IA-8 and positive control fluralaner in the active site of GABA. Molecular structure comparisons and ADMET analysis can potentially be used to design more active compounds. The structure-activity relationships are also discussed. This work provided an excellent insecticide for further optimization.

Keywords

GABA; SAR; aryl isoxazoline compounds; molecular docking; synthesis.

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