2. Academic Validation
  3. Asteriquinones from Aspergillus sp. GZWMJZ-258 and Their Derivatives

Asteriquinones from Aspergillus sp. GZWMJZ-258 and Their Derivatives

  • J Nat Prod. 2023 Nov 24;86(11):2522-2528. doi: 10.1021/acs.jnatprod.3c00732.
Liping Wang 1 2 3,  Wenwen He 1 2,  Xiaoyang Wang 1 2 3,  Gang Li 1,  Dongyang Wang 1 2,  Yanchao Xu 1 3,  Weiming Zhu 1 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
  • 2 Natural Products Research Center of Guizhou Province, Guiyang 550014, China.
  • 3 School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China.
  • 4 Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao 266237, China.
PMID: 37857311 DOI: 10.1021/acs.jnatprod.3c00732
Abstract

A new asteriquinone, ochrindole F (1), and five previously reported analogues (2-6) were isolated from the culture of the fungus Aspergillus sp. GZWMJZ-258, an endophyte of Garcinia multiflora. The structure of compound 1 was determined by a spectroscopic analysis. Furthermore, eight new derivatives (7-14) were synthesized from major metabolites 2 and 3. These compounds showed selective antiproliferative activity against the human acute myeloid leukemia (AML) cell line MV4-11, among which compound 12 showed the strongest activity with an IC50 value of 0.14 μM and the highest selectivity with a selectivity index greater than 710. An initial probe of the mechanism of action showed that compounds 12 and 14 could inhibit the expression of Flt-3 in the MV4-11 cell line.

Figures