Bcl-B: an "unknown" protein of the Bcl-2 family

Biol Direct. 2023 Oct 30;18(1):69. doi: 10.1186/s13062-023-00431-4.

N V Pervushin ¹ ², G S Kopeina ³ ⁴, B Zhivotovsky ⁵ ⁶ ⁷

Affiliations

1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
2 Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia.
3 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. [email protected].
4 Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia. [email protected].
5 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. [email protected].
6 Faculty of Medicine, MV Lomonosov Moscow State University, Moscow, 119991, Russia. [email protected].
7 Division of Toxicology, Institute of Environmental Medicine, Karolinska Institute, Box 210, Stockholm, 17177, Sweden. [email protected].

PMID: 37899453 DOI: 10.1186/s13062-023-00431-4

Abstract

Bcl-B is a poorly understood protein of the Bcl-2 Family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different Cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B.

Keywords

Bcl-2 family proteins; Bcl-B/Bcl-2L10; Carcinogenesis; Embryogenesis; Oogenesis; Programmed cell death.

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