2. Academic Validation
  3. Unlocking the synthetic approaches and clinical application of approved small-molecule drugs for gastrointestinal cancer treatment: A comprehensive exploration

Unlocking the synthetic approaches and clinical application of approved small-molecule drugs for gastrointestinal cancer treatment: A comprehensive exploration

  • Eur J Med Chem. 2023 Dec 15:262:115928. doi: 10.1016/j.ejmech.2023.115928.
Xiao-Jing Li 1,  Peng Nie 2,  Piet Herdewijn 3,  Jian-Gang Sun 4
Affiliations

Affiliations

  • 1 Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
  • 2 Medicinal Chemistry, Rega Institute of Medical Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. Electronic address: [email protected].
  • 3 Medicinal Chemistry, Rega Institute of Medical Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. Electronic address: [email protected].
  • 4 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. Electronic address: [email protected].
PMID: 37944387 DOI: 10.1016/j.ejmech.2023.115928
Abstract

Gastrointestinal (GI) cancers encompass a group of malignancies affecting the digestive system, including the stomach, esophagus, liver, colon, rectum and pancreas. These cancers represent a significant global health burden, necessitating effective treatment strategies. Small-molecule drugs have emerged as crucial therapeutic options in the fight against GI cancers due to their oral bioavailability, targeted mechanisms of action, and well-established safety profiles. The review then elucidates the clinical applications and synthetic methods of clinically approved small-molecule drugs for the treatment of GI Cancer, shedding light on their mechanisms of action and their potential in mitigating GI Cancer progression. The review also discusses future prospects and the evolving landscape of small-molecule drug development in GI oncology, highlighting the potential for personalized medicine. In summary, this review provides valuable insights into cutting-edge strategies for harnessing clinically approved small-molecule drugs to combat GI Cancer effectively.

Keywords

Clinical applications; Drugs; Gastrointestinal cancer; Synthesis.

Figures