2. Academic Validation
  3. Evaluation of a First PET Tracer Suitable for Imaging the Sigma-2 Receptor in the Brain of Nonhuman Primates

Evaluation of a First PET Tracer Suitable for Imaging the Sigma-2 Receptor in the Brain of Nonhuman Primates

  • Mol Pharm. 2024 Jan 1;21(1):194-200. doi: 10.1021/acs.molpharmaceut.3c00750.
Santosh Reddy Alluri 1,  MingQiang Zheng 1,  Daniel Holden 1,  Ying Zhang 2,  Li Zhang 1,  Zachary Felchner 1,  Songye Li 1,  Jim Ropchan 1,  Richard Carson 1,  Hongmei Jia 2,  Yiyun Huang 1
Affiliations

Affiliations

  • 1 PET Center, Yale University, New Haven, Connecticut 06520, United States.
  • 2 College of Chemistry, Beijing Normal University, Beijing 100875, China.
PMID: 38013422 DOI: 10.1021/acs.molpharmaceut.3c00750
Abstract

The sigma-2 receptor (σ2R), recently identified as transmembrane protein 97, is expressed in many cell types and mediates important functions in both the peripheral and central nervous systems. Over the years, σ2R has emerged as a potential therapeutic target for Cancer and neurological disorders such as Alzheimer's disease (AD). The currently available σ2R radiotracers have been developed primarily for Cancer imaging with limited brain uptake. Here, we report the evaluation of the first brain penetrant 18F-labeled radiotracer suitable for positron emission tomography (PET) imaging of σ2R in nonhuman primate brain.

Keywords

SYB4; brain imaging; nonhuman primate; radiotracer; sigma-2.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-163075
    PET Tracer