2. Academic Validation
  3. Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma

Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma

  • Int J Cancer. 2024 Jan 11. doi: 10.1002/ijc.34844.
Xiaojiang Wang 1 2 3,  Jiandong Sun 1 3,  Yue Liu 1 3,  Zihang Lin 1 3,  Xia Jiang 1 3,  Yuhong Ye 1 3 4,  Chengyu Lv 1 3 5,  Xiuli Lian 1 3,  Weiwei Xu 1 3,  Shanshan Luo 1 3,  Shumin Liao 1 3,  Zhangting Chen 1 3,  Shie Wang 1 3
Affiliations

Affiliations

  • 1 Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Province University, Fujian Medical University, Fuzhou, China.
  • 2 Department of Molecular Pathology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.
  • 3 Department of Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
  • 4 Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • 5 Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China.
PMID: 38212905 DOI: 10.1002/ijc.34844
Abstract

TRPS1 is aberrantly expressed in a variety of tumors, including breast, prostate, and gastric cancers, and is strongly associated with tumorigenesis or prognosis. However, the role of TRPS1 in high grade serous ovarian carcinoma (HGSC) is unknown. We investigated the relationship between TRPS1 expression and clinicopathology in HGSC patients. The tumor-related regulatory mechanisms of TRPS1 was explored through in vivo and vitro experiments. The results showed that TRPS1 was highly expressed in HGSC compared to normal tissues. It was also linked to the cell proliferation index Ki67 and poor prognosis. In vivo experiments showed that knockdown of TRPS1 could inhibit tumor growth. In vitro experiments, knockdown of TRPS1 inhibited the proliferation of ovarian Cancer cells. TRPS1 exerted its regulatory role as a transcription factor, binding to the PSAT1 promoter and promoting the expression of PSAT1 gene. Meanwhile, PSAT1 was positively correlated with CCND1 expression. These results suggest that TRPS1 affects HGSC proliferation and cell cycle by regulating PSAT1 and thus CCND1 expression.

Keywords

cell cycle; high grade serous ovarian carcinoma; phosphoserine transaminase 1; trichorhinophalangeal syndrome 1.

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