Latest developments in coumarin-based anticancer agents: mechanism of action and structure-activity relationship studies

RSC Med Chem. 2023 Oct 20;15(1):10-54. doi: 10.1039/d3md00511a.

Manankar Koley ¹, Jianlin Han ², Vadim A Soloshonok ³ ⁴, Subhajit Mojumder ¹, Ramin Javahershenas ⁵, Ata Makarem ⁶

Affiliations

1 CSIR-Central Glass & Ceramic Research Institute Kolkata India.
2 College of Chemical Engineering, Nanjing Forestry University Nanjing China.
3 Department of Organic Chemistry I, University of the Basque Country San Sebastián Spain.
4 IKERBASQUE, Basque Foundation for Science Bilbao Spain.
5 Department of Organic Chemistry, Faculty of Chemistry, Urmia University Urmia Iran.
6 Institute of Pharmacy, University of Hamburg Hamburg Germany [email protected].

PMID: 38283214 DOI: 10.1039/d3md00511a

Abstract

Many researchers around the world are working on the development of novel Anticancer drugs with different mechanisms of action. In this case, coumarin is a highly promising pharmacophore for the development of novel Anticancer drugs. Besides, the hybridization of this moiety with other Anticancer pharmacophores has emerged as a potent breakthrough in the treatment of Cancer to decrease its side effects and increase its efficiency. This review aims to provide a comprehensive overview of the recent development of coumarin derivatives and their application as novel Anticancer drugs. Herein, we highlight and describe the largest number of research works reported in this field from 2015 to August 2023, along with their mechanisms of action and structure-activity relationship studies, making this review different from the Other review articles published on this topic to date.

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