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  2. Pattern recognition of microcirculation with super-resolution ultrasound imaging provides markers for early tumor response to anti-angiogenic therapy

Pattern recognition of microcirculation with super-resolution ultrasound imaging provides markers for early tumor response to anti-angiogenic therapy

  • Theranostics. 2024 Jan 20;14(3):1312-1324. doi: 10.7150/thno.89306.
Jingyi Yin 1 Feihong Dong 2 3 4 Jian An 1 Tianyu Guo 2 Heping Cheng 2 3 4 5 Jiabin Zhang 2 3 4 Jue Zhang 1 4 5 6
Affiliations

Affiliations

  • 1 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • 2 College of Future Technology, Peking University, Beijing, China.
  • 3 State Key Laboratory of Membrane Biology, Peking-Tsinghua Center for Life Sciences, and Institute of Molecular Medicine, Peking University, Beijing, China.
  • 4 National Biomedical Imaging Center, Peking University, Beijing, China.
  • 5 Research Unit of Mitochondria in Brain Diseases, Chinese Academy of Medical Sciences, PKU-Nanjing Institute of Translational Medicine, Nanjing, China.
  • 6 College of Engineering, Peking University, Beijing, China.
Abstract

Rationale: Cancer treatment outcome is traditionally evaluated by tumor volume change in clinics, while tumor microvascular heterogeneity reflecting tumor response has not been fully explored due to technical limitations. Methods: We introduce a new paradigm in super-resolution ultrasound imaging, termed pattern recognition of microcirculation (PARM), which identifies both hemodynamic and morphological patterns of tumor microcirculation hidden in spatio-temporal space trajectories of microbubbles. Results: PARM demonstrates the ability to distinguish different local blood flow velocities separated by a distance of 24 μm. Compared with traditional vascular parameters, PARM-derived heterogeneity parameters prove to be more sensitive to microvascular changes following anti-angiogenic therapy. Particularly, PARM-identified "sentinel" microvasculature, exhibiting evident structural changes as early as 24 hours after treatment initiation, correlates significantly with subsequent tumor volume changes (|r| > 0.9, P < 0.05). This provides prognostic insight into tumor response much earlier than clinical criteria. Conclusions: The ability of PARM to noninvasively quantify tumor vascular heterogeneity at the microvascular level may shed new LIGHT on early-stage assessment of Cancer therapy.

Keywords

Anti-angiogenic treatment; Pattern recognition; Super-resolution ultrasound imaging; Tumor heterogeneity; Tumor microvasculature.

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