2. Academic Validation
  3. Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis

Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis

  • J Nat Prod. 2024 Feb 23;87(2):349-357. doi: 10.1021/acs.jnatprod.3c01094.
Patcharee Pripdeevech 1 2,  Sarunpron Khruengsai 1,  Chutima Tanapichatsakul 1,  Wael M Afifi 3 4,  Winnie Chemutai Sum 5,  Kevin D Hyde 1 2,  Sherif S Ebada 6
Affiliations

Affiliations

  • 1 School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand.
  • 2 Center of Chemical Innovation for Sustainability (CIS), Mae Fah Luang University, Chiang Rai 57100, Thailand.
  • 3 Department of Pharmacongosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University, 11884 Cairo, Egypt.
  • 4 Department of Pharmacognosy, Faculty of Pharmacy, Sinai University-Kantara Branch, 41636 Ismailia, Egypt.
  • 5 Department of Biochemistry, Egerton University, P.O.536-20115 Egerton-Njoro, Kenya.
  • 6 Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbasia, 11566 Cairo, Egypt.
PMID: 38351796 DOI: 10.1021/acs.jnatprod.3c01094
Abstract

Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The fungus Neodidymelliopsis negundinis presents a significant saprobic ascomycete whose metabolites remained hitherto unstudied. Herein we report the isolation of eight unprecedented secondary metabolites named neodidymelliosides A and B (1 and 2), neodidymelliol A (3), and neodidymellioic acids A-E (4-8) produced by the submerged cultures of the fungus. Compound 1 proved to be the most active compound, with IC50 values ranging between 4.8 and 8.8 μM against KB3.1 (cervix), PC-3 (prostate), MCF-7 (breast), SKOV-3 (ovary), A431 (skin), and A549 (lung) cell lines. Compound 1 revealed significant inhibition of Staphylococcus aureus and Candida albicans biofilms.

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