2. Academic Validation
  3. Self-assembly of PEG-PPS polymers and LL-37 peptide nanomicelles improves the oxidative microenvironment and promotes angiogenesis to facilitate chronic wound healing

Self-assembly of PEG-PPS polymers and LL-37 peptide nanomicelles improves the oxidative microenvironment and promotes angiogenesis to facilitate chronic wound healing

  • Bioeng Transl Med. 2023 Nov 8;9(2):e10619. doi: 10.1002/btm2.10619.
Rong Shi 1 2,  Jianxiong Qiao 1,  Quanwu Sun 2,  Biao Hou 3,  Bo Li 3,  Ji Zheng 4,  Zhenzhen Zhang 1,  Zhenxue Peng 1,  Jing Zhou 1,  Bingbing Shen 5,  Jun Deng 6,  Xuanfen Zhang 1
Affiliations

Affiliations

  • 1 Department of Plastic Surgery Lanzhou University Second Hospital Lanzhou Gansu China.
  • 2 Department of Breast Surgery Gansu Provincial Hospital Lanzhou Gansu China.
  • 3 Department of Joint Surgery and Sports Medicine Center for Orthopedic Surgery, Orthopedic Hospital of Guangdong Province, The Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong China.
  • 4 Department of Urology Xinqiao Hospital, Third Military Medical University (Army Medical University) Chongqing China.
  • 5 Department of Nephrology Chongqing University Central Hospital, Chongqing Emergency Medical Center Chongqing China.
  • 6 Institute of Burn Research, State Key Lab of Trauma, Burn, and Combined Injury, Chongqing Key Laboratory for Disease Proteomics Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing China.
PMID: 38435813 DOI: 10.1002/btm2.10619
Abstract

Refractory diabetic wounds are associated with high incidence, mortality, and recurrence rates and are a devastating and rapidly growing clinical problem. However, treating these wounds is difficult owing to uncontrolled inflammatory microenvironments and defective angiogenesis in the affected areas, with no established effective treatment to the best of our knowledge. Herein, we optimized a dual functional therapeutic agent based on the assembly of LL-37 peptides and diblock copolymer poly(ethylene glycol)-poly(propylene sulfide) (PEG-PPS). The incorporation of PEG-PPS enabled responsive or controlled LL-37 peptide release in the presence of Reactive Oxygen Species (ROS). LL-37@PEG-PPS nanomicelles not only scavenged excessive ROS to improve the microenvironment for angiogenesis but also released LL-37 peptides and protected them from degradation, thereby robustly increasing angiogenesis. Diabetic wounds treated with LL-37@PEG-PPS exhibited accelerated and high-quality wound healing in vivo. This study shows that LL-37@PEG-PPS can restore beneficial angiogenesis in the wound microenvironment by continuously providing angiogenesis-promoting signals. Thus, it may be a promising drug for improving chronic refractory wound healing.

Keywords

LL‐37@PEG–PPS nanomicelles; angiogenesis; diabetic wound healing; inflammatory microenvironment.

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