2. Academic Validation
  3. Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

  • J Nat Prod. 2024 Apr 26;87(4):1067-1074. doi: 10.1021/acs.jnatprod.4c00022.
Ulises G Castillo 1,  Yoshinori Uekusa 2,  Takehiro Nishimura 2,  Fumiyuki Kiuchi 2,  Morena L Martínez 1,  Jenny Menjívar 3,  Junko Nakajima-Shimada 4,  Marvin J Núñez 1,  Haruhisa Kikuchi 2
Affiliations

Affiliations

  • 1 Laboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Avenida de Mártires y Héroes del 30 de Julio, San Salvador 1101, El Salvador.
  • 2 Faculty of Pharmacy, Keio University, 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
  • 3 Museo de Historia Natural de El Salvador, Ministerio de Cultura, San Salvador 1101, El Salvador.
  • 4 Graduate School of Health Science, Gunma University, 3-39-22 Showamachi, Maebashi, Gunma 371-8514, Japan.
PMID: 38631020 DOI: 10.1021/acs.jnatprod.4c00022
Abstract

A search for anti-trypanosomal natural compounds from Plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.

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