2. Academic Validation
  3. Biological Implications and Functional Significance of Transglutaminase Type 2 in Nervous System Tumors

Biological Implications and Functional Significance of Transglutaminase Type 2 in Nervous System Tumors

  • Cells. 2024 Apr 11;13(8):667. doi: 10.3390/cells13080667.
Mariachiara Buccarelli 1,  Giorgia Castellani 1,  Vincenzo Fiorentino 2,  Cristina Pizzimenti 3,  Simone Beninati 4,  Lucia Ricci-Vitiani 1,  Maria Luisa Scattoni 5,  Carlo Mischiati 6,  Francesco Facchiano 1,  Claudio Tabolacci 5
Affiliations

Affiliations

  • 1 Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
  • 2 Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
  • 3 Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, 98125 Messina, Italy.
  • 4 Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • 5 Research Coordination and Support Service, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
  • 6 Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
PMID: 38667282 DOI: 10.3390/cells13080667
Abstract

Transglutaminase type 2 (TG2) is the most ubiquitously expressed member of the Transglutaminase family. TG2 catalyzes the transamidation reaction leading to several protein post-translational modifications and it is also implicated in signal transduction thanks to its GTP binding/hydrolyzing activity. In the nervous system, TG2 regulates multiple physiological processes, such as development, neuronal cell death and differentiation, and synaptic plasticity. Given its different enzymatic activities, aberrant expression or activity of TG2 can contribute to tumorigenesis, including in peripheral and central nervous system tumors. Indeed, TG2 dysregulation has been reported in meningiomas, medulloblastomas, neuroblastomas, glioblastomas, and Other adult-type diffuse gliomas. The aim of this review is to provide an overview of the biological and functional relevance of TG2 in the pathogenesis of nervous system tumors, highlighting its involvement in survival, tumor inflammation, differentiation, and in the resistance to standard therapies.

Keywords

TGM2 gene; crosslinking; glioma; multifunctional enzyme; nervous system tumors; neuroblastoma; transglutaminase 2.

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