2. Academic Validation
  3. The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases

The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases

  • J Transl Med. 2024 May 24;22(1):490. doi: 10.1186/s12967-024-05293-6.
Xudong Wu 1,  Hui Chen 1,  Kai Li 1,  Hong Zhang 1,  Kai Li 2,  Haoyu Tan 3
Affiliations

Affiliations

  • 1 Department of Thoracic Surgery, The Third Hospital of Changsha, Changsha, 410015, Hunan, People's Republic of China.
  • 2 Department of Thoracic Surgery, Xiangxi Autonomous Prefecture People's Hospital, Jishou, 410015, Hunan, People's Republic of China.
  • 3 Department of Cardio-vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, People's Republic of China. [email protected].
PMID: 38790013 DOI: 10.1186/s12967-024-05293-6
Abstract

N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating RNA stability, translation, and transcription. All members within the YT521-B homology (YTH) gene family are categorized as m6A reading proteins, capable of identifying and binding m6A modifications on RNA, thereby regulating RNA metabolism and functioning across diverse physiological processes. YTH domain-containing 2 (YTHDC2), identified as the latest member of the YTH family, has only recently started to emerge for its biological function. Numerous studies have underscored the significance of YTHDC2 in human physiology, highlighting its involvement in both tumor progression and non-tumor diseases. Consequently, this review aims to further elucidate the pathological mechanisms of YTHDC2 by summarizing its functions and roles in tumors and Other Diseases, with a particular focus on its downstream molecular targets and signaling pathways.

Keywords

Biomarkers; N6-methyladenosine; Tumor biology; YTHDC2; m6A.

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