2. Academic Validation
  3. Design, synthesis, and biological antitumor evaluation of tetrahydroisoquinoline derivatives

Design, synthesis, and biological antitumor evaluation of tetrahydroisoquinoline derivatives

  • Bioorg Med Chem Lett. 2024 Sep 1:109:129824. doi: 10.1016/j.bmcl.2024.129824.
Can Pang 1,  Jianbo Zhao 1,  Shuai Zhang 1,  Jiayu Chen 1,  Xiu Zeng 1,  Hao Li 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, and School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
  • 2 State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, and School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: [email protected].
PMID: 38823729 DOI: 10.1016/j.bmcl.2024.129824
Abstract

Cancer, as a public health issue, is the leading cause of death worldwide. Tetrahydroisoquinoline derivatives have effective biological activities and can be used as potential therapeutic agents for antitumor drugs. In this work, we designed and synthesized a series of novel tetrahydroisoquinoline compounds and evaluated their antitumor activity in vitro on several representative human Cancer cell lines. The results showed that the vast majority of compounds showed good inhibitory activities against the Cancer cell lines of HCT116, MDA-MB-231, HepG2, and A375.

Keywords

Antitumor; In vitro; Quaternary ammonium salt; Synthesis; Tetrahydroisoquinoline.

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