2. Academic Validation
  3. Undobolins A-L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus

Undobolins A-L, Ophiobolin-Type Sesterterpenoids from Aspergillus undulatus

  • J Nat Prod. 2024 Aug 23;87(8):1965-1974. doi: 10.1021/acs.jnatprod.4c00385.
Yuyi Zheng 1,  Qin Li 1,  Minglang Gu 1,  Hong Liao 1,  Yu Liang 1,  Fei Liu 1,  Xiao-Nian Li 2,  Weiguang Sun 1,  Chunmei Chen 1,  Yonghui Zhang 1,  Hucheng Zhu 1
Affiliations

Affiliations

  • 1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 39051441 DOI: 10.1021/acs.jnatprod.4c00385
Abstract

Twelve previously undescribed ophiobolin-type sesterterpenoids, undobolins A-L (1-12), were isolated from Aspergillus undulatus, and their structures were elucidated by spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction experiments. Compound 1 was the second example of 20-nor-ophiobolin reported, while compounds 2-6 were notable for oxygenation of C-2, and compound 6 showed significant inhibitory activity against ConA-induced T lymphocyte proliferation with an IC50 value of 2.3 μM, which suggests a promising new direction in the quest for immunosuppressive agents.

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