2. Academic Validation
  3. Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway

Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway

  • iScience. 2024 Jul 8;27(8):110448. doi: 10.1016/j.isci.2024.110448.
Jun Zhang 1,  Yongjian Zhao 1,  Lin Yan 1,  Mingyue Tan 1,  Yifeng Jin 1,  Yunfei Yin 1,  Lianhua Han 1,  Xiao Ma 1,  Yimin Li 1,  Tianke Yang 2,  Tingbo Jiang 1,  Hongxia Li 1
Affiliations

Affiliations

  • 1 Department of Cardiology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu 215006, P.R. China.
  • 2 Department of Ophthalmology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, P.R. China.
PMID: 39091464 DOI: 10.1016/j.isci.2024.110448
Abstract

Despite advances in treatment, myocardial infarction remains the leading cause of heart failure and death worldwide, and the restoration of coronary blood flow can also cause heart damage. In this study, we found that corosolic acid (CA), also known as plant Insulin, significantly protects the heart from ischemia-reperfusion (I/R) injury. In addition, CA can inhibit oxidative stress and improve mitochondrial structure and function in cardiomyocytes. Subsequently, our study demonstrated that CA improved the expression of the mitophagy-related proteins Prohibitin 2 (PHB2), PTEN-induced putative kinase protein-1 (PINK1), and Parkin. Meanwhile, through molecular docking, we found an excellent binding between CA and PHB2 protein. Finally, the knockdown of PHB2 eliminated the protective effect of CA on hypoxia-reoxygenation in cardiomyocytes. Taken together, our study reveals that CA increases Mitophagy in cardiomyocytes via the PHB2/PINK1/Parkin signaling pathway, inhibits oxidative stress response, and maintains mitochondrial function, thereby improving cardiac function after I/R.

Keywords

biochemistry; cell biology; molecular biology; physiology.

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