1. Autophagy Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  2. Autophagy Apoptosis EGFR
  3. Corosolic acid

Corosolic acid  (Synonyms: Colosolic acid)

Cat. No.: HY-N0280 Purity: 99.23%
COA Handling Instructions

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis.

For research use only. We do not sell to patients.

Corosolic acid Chemical Structure

Corosolic acid Chemical Structure

CAS No. : 4547-24-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 75 In-stock
25 mg USD 140 In-stock
50 mg USD 210 In-stock
100 mg USD 310 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis[1][2][3].

In Vitro

Corosolic acid shows cytotoxicity for Hep G2, A549, SNU-C4, HeLa, K-562 cells, with ED50s of 0.4-5.0 μg/mL[1].
Corosolic acid (0-50 μg/mL) inhibits PKC activity in a dose-dependent way[1].
Corosolic acid (0-50 μM, 6-24 h) induces apoptosis and increases cells in the sub-G1 population in CT-26 cells[3].
Corosolic acid (20 μM, 0-24 h) inhibits HER2/HER3 heterodimerization and phosphorylation of HER2 and HER3 in HCT116 and SW480 cells[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[3]

Cell Line: CT-26 cells
Concentration: 25 µM
Incubation Time: 12 and 24 h
Result: Increased cleaved caspase-3 level.
Increased cells in the sub-G1 population.
Increased fluorescin-dUTP labeling DNA strand breaks.

Western Blot Analysis[5]

Cell Line: HCT116 and SW480 cells
Concentration: 20 μM
Incubation Time: 0-24 h
Result: Decreased the formation of NRG1-induced HER2/HER3 heterodimer.
Inhibited the PI3K/Akt/PDE3B but not the ERK1/2 signaling pathway.
In Vivo

Corosolic acid (5, 25 mg/kg/day, peritumor injection, 12 days) inhibits tumor growth and shows anti-angiogenic effect in CT-26 allograft colon carcinoma mice model[3].
Corosolic acid (10 and 20 mg/kg, i.p., every 2 days) inhibits tumor growth in a murine PC-3 xenograft model by activating ER stress[4].
Corosolic acid (10 mg/kg/d, supplemented in diet, 8 weeks) inhibits adipose tissue inflammation, and improves insulin resistance via AMPK activation in high-fat fed mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT-26 allograft colon carcinoma mice model[3]
Dosage: 5, 25 mg/kg/day
Administration: Peritumor injection, 12 days
Result: Reduced the tumor weight to 76.2% and 53.8% of the control group.
Reduced blood and lymphatic vessel densities.
Animal Model: high-fat fed mice[6]
Dosage: 10 mg/kg/day
Administration: Supplemented in diet, 8 weeks
Result: Inhibited hyperlipidemia, Improved insulin sensitivity and glucose intolerance.
Inhibited inflammation in adipose tissues.
Inhibited macrophage infiltrations into adipose tissue.
Molecular Weight

472.70

Formula

C30H48O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (52.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1155 mL 10.5775 mL 21.1551 mL
5 mM 0.4231 mL 2.1155 mL 4.2310 mL
10 mM 0.2116 mL 1.0578 mL 2.1155 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.75 mg/mL (5.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.23%

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Corosolic acid
Cat. No.:
HY-N0280
Quantity:
MCE Japan Authorized Agent: