2. Academic Validation
  3. β-Amyloids and Immune Responses Associated with Alzheimer's Disease

β-Amyloids and Immune Responses Associated with Alzheimer's Disease

  • Cells. 2024 Sep 28;13(19):1624. doi: 10.3390/cells13191624.
Elizaveta Kolobova 1 2,  Irina Petrushanko 1,  Vladimir Mitkevich 1,  Alexander A Makarov 1,  Irina L Grigorova 1 2
Affiliations

Affiliations

  • 1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
  • 2 Institute of Translational Medicine, Pirogov Russian National Research Medical University, 117513 Moscow, Russia.
PMID: 39404388 DOI: 10.3390/cells13191624
Abstract

Alzheimer's disease (AD) is associated with the accumulation of β-amyloids (Aβs) and the formation of Aβ plaques in the brain. Various structural forms and isoforms of Aβs that have variable propensities for oligomerization and toxicity and may differentially affect the development of AD have been identified. In addition, there is evidence that β-amyloids are engaged in complex interactions with the innate and adaptive immune systems, both of which may also play a role in the regulation of AD onset and progression. In this review, we discuss what is currently known about the intricate interplay between β-amyloids and the immune response to Aβs with a more in-depth focus on the possible roles of B cells in the pathogenesis of AD.

Keywords

Alzheimer’s disease; B cells; antibody; immune response; post-translational modifications of β-amyloid; β-amyloid.

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