2. Academic Validation
  3. Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects

Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects

  • Food Sci Nutr. 2024 Jul 31;12(10):6970-6989. doi: 10.1002/fsn3.4376.
Simona Sestito 1,  Roberta Ibba 2,  Federico Riu 3,  Sara Carpi 4 5,  Antonio Carta 2,  Clementina Manera 6,  Solomon Habtemariam 7,  Balakyz Yeskaliyeva 8,  Zainab M Almarhoon 9,  Javad Sharifi-Rad 10 11,  Simona Rapposelli 6
Affiliations

Affiliations

  • 1 Department of Chemical, Physical, Mathematical and Natural Sciences University of Sassari Sassari Italy.
  • 2 Department of Medicine, Surgery and Pharmacy University of Sassari Sassari Italy.
  • 3 Department of Chemistry-BMC Uppsala University Uppsala Sweden.
  • 4 NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore Pisa Italy.
  • 5 Department of Health Sciences University 'Magna Græcia' of Catanzaro Catanzaro Italy.
  • 6 Department of Pharmacy University of Pisa Pisa Italy.
  • 7 Pharmacognosy Research & Herbal Analysis Services UK University of Greenwich Kent UK.
  • 8 Faculty of Chemistry and Chemical Technology Al-Farabi Kazakh National University Almaty Kazakhstan.
  • 9 Department of Chemistry, College of Science King Saud University Riyadh Saudi Arabia.
  • 10 Department of Biomedical Sciences College of Medicine, Korea University Seoul Republic of Korea.
  • 11 Centro de Estudios Tecnológicos y Universitarios del Golfo Veracruz Mexico.
PMID: 39479643 DOI: 10.1002/fsn3.4376
Abstract

Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in Cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots - decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in Cancer treatment. Biotechnological strategies for enhanced production and semisynthetic derivatives with Anticancer properties are discussed. The study emphasizes the promising pharmacological potential of decursin, DA, and DOH in various therapeutic applications, particularly Cancer treatment. The review also underscores innovative approaches to increase production and explores semisynthetic derivatives as a promising avenue for future natural product-based drug discovery. This concise overview provides valuable insights into the potential of AGN-derived compounds in the field of natural product-based therapeutics.

Keywords

anticancer; decursin; decursinol; natural product; traditional medicine.

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