2. Academic Validation
  3. I don't know about you, but I'm feeling IL-22

I don't know about you, but I'm feeling IL-22

  • Cytokine Growth Factor Rev. 2024 Dec:80:1-11. doi: 10.1016/j.cytogfr.2024.11.001.
Logan S Dean 1,  Alissa N Threatt 2,  Kaylee Jones 2,  Emmanuel O Oyewole 2,  Morgan Pauly 3,  Maëlis Wahl 4,  Melea Barahona 1,  Rose W Reiter 5,  Tara M Nordgren 6
Affiliations

Affiliations

  • 1 Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80521, United States; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, United States.
  • 2 Toxicology Graduate Program, Colorado State University, Fort Collins, CO 80521, United States; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, United States.
  • 3 Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, United States.
  • 4 Department of Biochemistry and Molecular Biology, Colorado State University, CO 80521, United States.
  • 5 Department of Molecular, Cellular, and Integrative Neuroscience, Colorado State University, CO 80521, United States.
  • 6 Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80521, United States; Toxicology Graduate Program, Colorado State University, Fort Collins, CO 80521, United States; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80521, United States. Electronic address: [email protected].
PMID: 39537498 DOI: 10.1016/j.cytogfr.2024.11.001
Abstract

Defense of the human body against damaging and pathogenic insults is a heavily regulated affair. A primary mechanism of defense at sites of insult are soluble mediators whose defensive maneuvers increase barrier integrity and promote pro-reparative and resolution processes. IL-22 is a cytokine in the IL-10 cytokine family that has garnered increased attention in recent years due to its intimate link in promoting resolution of inflammatory insults, while simultaneously being over expressed in certain fibrotic and chronic inflammatory-skewed diseases. The spatial action of IL-22 centers around the barrier sites of the body, including the skin, lungs, and gut mucosa. As such, a detailed understanding of the role of this cytokine, the producers and responders, and the diseases resulting from over- or under-expression have prominent impacts on a variety of disease outcomes. Herein we present a comprehensive review of IL-22; from historical perspectives and initial discovery, as well as more recent data that dramatically expands on the cellular sources and impact of this cytokine. We aim to showcase the duality of IL-22 and highlight addressable gaps in the field of IL-22 crosstalk and impacts at the ever-important mucosal and tissue barrier sites.

Keywords

Epithelial integrity; IL-22; ILC’s; Inflammation; Macrophages; Pro-resolution.

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