2. Academic Validation
  3. Deferoxamine functionalized alginate-based collagen composite material enhances the integration of metal implant and bone interface

Deferoxamine functionalized alginate-based collagen composite material enhances the integration of metal implant and bone interface

  • Carbohydr Polym. 2025 Feb 1;349(Pt A):122944. doi: 10.1016/j.carbpol.2024.122944.
Zhenjia Che 1,  Xiao Sheng 2,  Qi Sun 3,  Yanglin Wu 3,  Kaihang Song 3,  Aopan Chen 3,  Jing Chen 3,  Qiyun Chen 3,  Ming Cai 4
Affiliations

Affiliations

  • 1 Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, People's Republic of China. Electronic address: [email protected].
  • 2 Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Wuxing, Huzhou, Zhejiang 313000, People's Republic of China.
  • 3 Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, People's Republic of China.
  • 4 Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, People's Republic of China. Electronic address: [email protected].
PMID: 39643405 DOI: 10.1016/j.carbpol.2024.122944
Abstract

Poor osseointegration markedly compromises the longevity of prostheses. To enhance the stability of titanium implants, surface functionalization is a proven strategy to promote prosthesis-bone integration. This study developed a hydrogel coating capable of simultaneous osteoangiogenesis and vascularization by incorporating deferoxamine (DFO) into a sodium alginate mineralized Collagen composite hydrogel. The physicochemical properties of this hydrogel were thoroughly analyzed. In vivo and in vitro experiments confirmed the hydrogel scaffold's osteogenic and angiogenic capabilities. Results indicated that sodium alginate notably enhanced the mechanical characteristics of the mineralized Collagen, allowing it to fully infiltrate the interstices of the 3D-printed titanium scaffold. Furthermore, as the hydrogel degraded, Collagen, calcium ion, phosphate ion, and DFO were gradually released around the scaffolds, altering the local osteogenic microenvironment and strongly inducing new bone tissue growth. These findings offer novel perspectives for the creation and utilization of functionalized bone implant Materials.

Keywords

3D-printed porous titanium scaffold; Alginate; Angiogenesis; Deferoxamine; Mineralized collagen; Osseointegration.

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