2. Academic Validation
  3. Naphthalene derivatives and diarylheptanoids from the leaves of Cyclocarya paliurus and their α-glucosidase inhibitory activities

Naphthalene derivatives and diarylheptanoids from the leaves of Cyclocarya paliurus and their α-glucosidase inhibitory activities

  • Nat Prod Res. 2025 Feb 11:1-7. doi: 10.1080/14786419.2025.2462963.
Si-Yang Huang 1,  Pan-Pan Zhang 1,  Meng-Xia Yan 1,  Yang-Yang Wang 1,  Mei-Lan Yu 2,  De-Kai Wang 2,  Bo Yang 1
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
  • 2 College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China.
PMID: 39932367 DOI: 10.1080/14786419.2025.2462963
Abstract

A phytochemical study of the leaves of Cyclocarya paliurus led to the discovery of five naphthalene derivatives (1-5) and two diarylheptanoids (6-7), among which compounds 1 and 6 are new natural products. The structural elucidation of these new compounds was achieved through an in-depth examination of spectroscopic data, including NMR, MS, and IR. Their absolute configurations were established using electronic circular dichroism (ECD) calculation and dimolybdenum tetraacetate-induced circular dichroism CD (ICD) experiments. Notably, compound 7 exhibited inhibitory activity against α-glucosidase, demonstrating an IC50 value of 14.5 ± 3.3 µM.

Keywords

Cyclocarya paliurus; diarylheptanoid; naphthalene; α-glucosidase inhibitory activity.

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