2. Academic Validation
  3. Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

  • Nat Commun. 2025 Apr 3;16(1):3194. doi: 10.1038/s41467-025-58354-9.
Zihan Xu # 1 2 3,  Xiujing He # 1,  Yu Gui # 1,  Lingkai Tang # 4,  Yuxin Zhao 5,  Linlin Song 1,  Tianyue Xu 1,  Meixu Chen 1,  Yujie Zhao 1,  Peixin Du 1,  Xin Wang 1,  Siyi Chen 6,  Yong Luo 2 7,  Feng Luo 2 3,  Huan Meng 8,  Jianping Hu 4,  Wei Zhuo 9 10,  Jing Jing 11,  Hubing Shi 12
Affiliations

Affiliations

  • 1 Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China.
  • 2 Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 3 Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 4 Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, School of Pharmacy, Chengdu University, Chengdu, Sichuan, China.
  • 5 Department of Ultrasound, the Affiliated Hospital of Southwest Jiaotong University, the Third People's Hospital of Chengdu City, Chengdu, Sichuan, China.
  • 6 Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 7 Yingshan Hospital, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • 8 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China.
  • 9 Department of Colorectal Surgery and Oncology, Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. [email protected].
  • 10 Department of Cell Biology, Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. [email protected].
  • 11 Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China. [email protected].
  • 12 Institute of Breast Health Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China. [email protected].
  • # Contributed equally.
PMID: 40180981 DOI: 10.1038/s41467-025-58354-9
Abstract

Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the advanced stage, remains a major challenge for Cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O3P@LPYU), which can be triggered by physiological intrapleural pressure during breath. Under the gently alterative pressure, the piezoelectric nanoparticles with notable peroxidase-like activity effectively produce a burst of Reactive Oxygen Species and induce immunogenic cell death by catalysis of carried ozone as well as peroxide in interstitial fluid. A clear and sustained biodistribution is observed in thorax effusion and tumors upon intrapleural administration of particle. Remarkably, due to the abundant substrates in oxygen-rich environment of pleural cavity, O3P@LPYU particle provides a potent reduction of MPE volume and durable inhibition of tumor growth in thorax. Our work not only develops a bio-responsive piezoelectric nano-system, but also provides a strategy for persistent suppression of MPE in clinics.

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