2. Academic Validation
  3. Apoptotic vesicles inhibit bone marrow adiposity via wnt/β-catenin signaling

Apoptotic vesicles inhibit bone marrow adiposity via wnt/β-catenin signaling

  • Regen Ther. 2025 Mar 28:29:262-270. doi: 10.1016/j.reth.2025.03.012.
Yuan Zhu 1 2,  Yaoshan Liu 1,  Kunkun Yang 1,  Weiliang Wu 3,  Yawen Cheng 1,  Yanan Ding 1,  Ranli Gu 1,  Hao Liu 4 5,  Xiao Zhang 1 5,  Yunsong Liu 1 5
Affiliations

Affiliations

  • 1 Department of Prosthodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Beijing 100081, China.
  • 2 Department of Stomatology, Peking University Third Hospital, Beijing 100191, China.
  • 3 School and Hospital of Stomatology, Fujian Medical University, Fuzhou 350002, China.
  • 4 The Central Laboratory, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Beijing 100081, China.
  • 5 National Center of Stomatology, National Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
PMID: 40230357 DOI: 10.1016/j.reth.2025.03.012
Abstract

Background: There is currently increasing focus on aging-related diseases. Osteoporosis is a common disease the incidence of which increases with age. In older patients with osteoporosis, bone marrow mesenchymal stem cells (BMMSCs) have a decreased capacity for osteogenesis and an increased capacity for adipogenesis, causing excessive accumulation of adipose tissue in the bone marrow. Therefore, means of reducing bone marrow adiposity may have therapeutic potential for osteoporosis. Apoptotic vesicles (apoVs) participate in a wide range of physiological processes and have been shown to have therapeutic effects in a variety of diseases. The principal objective of this study was to examine the special properties and regulatory mechanisms of BMMSC-derived apoVs in the treatment of bone marrow adiposity.

Results: The results showed that apoVs could decrease bone marrow adiposity in osteoporotic mice and prevent adipogenic differentiation of MSCs by activating the Wnt/β-catenin pathway.

Conclusion: New apoV-based therapies have potential for the treatment of bone marrow adiposity in patients with aging-related osteoporosis and may be further applicable to the treatment of obesity and aging-related diseases.

Keywords

Aging-related diseases; Apoptotic vesicles; Bone marrow adiposity; Cell-free therapy; Wnt/β-catenin pathway.

Figures
Products