2. Academic Validation
  3. Low-Molecular-Weight Fucoidan Inhibits Thromboinflammation and Ameliorates Deep Vein Thrombosis via Targeting S100A8/A9

Low-Molecular-Weight Fucoidan Inhibits Thromboinflammation and Ameliorates Deep Vein Thrombosis via Targeting S100A8/A9

  • Mar Drugs. 2025 Apr 22;23(5):180. doi: 10.3390/md23050180.
Yiting Feng 1,  Weiqing Zhao 1,  Siwen Fang 1,  Jingwen Zhao 1,  Wanshuai Wang 1,  Shaoyun Zhou 1,  Tianyu Wang 1,  Xinke Fang 1,  Xue Chen 1,  Muhammad Awais 1,  Chao Cai 1 2 3,  Chuanbin Shen 1 2 3,  Ming Liu 1
Affiliations

Affiliations

  • 1 Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Chinese Ministry of Education, Qingdao 266000, China.
  • 2 Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266071, China.
  • 3 Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, Qingdao 266000, China.
PMID: 40422770 DOI: 10.3390/md23050180
Abstract

Deep vein thrombosis (DVT) is a prevalent life-threatening complication among hospitalized patients. DVT is characterized by the hypercoagulability and thromboinflammation in which platelet activation and neutrophil extracellular trap (NET) formation are critically involved. Studies have shown that S100A8/A9 is significantly elevated in patients with DVT, and is closely associated with platelet activation and NET formation. Fucoidan, the marine polysaccharide derived from Fucus algae, has potential anti-inflammatory and cardioprotective effects. We found low-molecular-weight fucoidan (LMF) bound to S100A8/A9 with an equilibrium dissociation constant (KD) of 2.368 × 10-8 M. LMF inhibited S100A8/A9-induced platelet hyperactivity and NET formation in vitro, and ameliorated DVT without significantly perturbing hemostasis in vivo. Our results indicate that the alarmin protein S100A8/A9 is a novel target of LMF. LMF may have therapeutic potential in S100A8/A9-induced thromboinflammation in DVT.

Keywords

S100A8/A9; deep vein thrombosis (DVT); neutrophil extracellular traps (NETs); polysaccharide; thromboinflammation.

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