2. Academic Validation
  3. Qinglongyi nanoparticles alleviate neuroinflammation and promote neuronal survival by inhibiting neuronal ferroptosis in intracerebral hemorrhage

Qinglongyi nanoparticles alleviate neuroinflammation and promote neuronal survival by inhibiting neuronal ferroptosis in intracerebral hemorrhage

  • Int Immunopharmacol. 2025 Jun 26:159:114945. doi: 10.1016/j.intimp.2025.114945.
Tao Yan 1,  Guiqiong Kang 2,  Yun Meng 2,  Liping Zhang 3,  Qing Jiang 4,  Na Shen 5,  Huadong Li 3,  Meifang Xu 2,  Lili Yu 5,  Guangpu Ni 3,  Haofeng Ma 3,  Feng Guo 6,  Yulei Cui 7,  Fengyuan Che 8
Affiliations

Affiliations

  • 1 Department of Neurology, Postgraduate Training Base of Linyi People's Hospital, Guangzhou University of Chinese Medicine, Linyi 276000, Shandong Province, China; Department of Neurosurgery, Linyi People's Hospital, Linyi 276000, Shandong Province, China; Shandong Provincial Clinical Research Center for Geriatric Diseases, Linyi 276000, Shandong Province, China; Key Laboratory of Neurophysiology, Health Commission of Shandong, Linyi 276000, Shandong Province, China; Linyi Key Laboratory of Neurophysiology, Key Laboratory for Translational Oncology, Xuzhou Medical University, Linyi 276000, Shandong Province, China.
  • 2 Department of Neurology, Postgraduate Training Base of Linyi People's Hospital, Guangzhou University of Chinese Medicine, Linyi 276000, Shandong Province, China; Shandong Provincial Clinical Research Center for Geriatric Diseases, Linyi 276000, Shandong Province, China; Key Laboratory of Neurophysiology, Health Commission of Shandong, Linyi 276000, Shandong Province, China; Linyi Key Laboratory of Neurophysiology, Key Laboratory for Translational Oncology, Xuzhou Medical University, Linyi 276000, Shandong Province, China.
  • 3 Department of Neurosurgery, Linyi People's Hospital, Linyi 276000, Shandong Province, China.
  • 4 Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
  • 5 School of Medicine, Linyi University, Linyi 276000, Shandong, China.
  • 6 Department of Neurosurgery, Linyi People's Hospital, Linyi 276000, Shandong Province, China. Electronic address: [email protected].
  • 7 School of Medicine, Linyi University, Linyi 276000, Shandong, China. Electronic address: [email protected].
  • 8 Department of Neurology, Postgraduate Training Base of Linyi People's Hospital, Guangzhou University of Chinese Medicine, Linyi 276000, Shandong Province, China; Shandong Provincial Clinical Research Center for Geriatric Diseases, Linyi 276000, Shandong Province, China; Key Laboratory of Neurophysiology, Health Commission of Shandong, Linyi 276000, Shandong Province, China; Linyi Key Laboratory of Neurophysiology, Key Laboratory for Translational Oncology, Xuzhou Medical University, Linyi 276000, Shandong Province, China. Electronic address: [email protected].
PMID: 40435822 DOI: 10.1016/j.intimp.2025.114945
Abstract

Intracerebral hemorrhage (ICH) is a severe cerebrovascular disorder with extremely high mortality and disability rates. Currently, effective medications for ICH are scarce, and the development of novel and efficacious drugs for its management is urgently needed. Neuronal Ferroptosis and neuroinflammation are important pathophysiological processes occurring during the progression of ICH. Nevertheless, the potential relationship between neuronal Ferroptosis and neuroinflammation during ICH remains to be clarified. Therefore, elucidating this relationship and further developing therapeutic drugs may provide feasible treatments for ICH. Here, we confirmed that ICH can induce neuronal Ferroptosis, which can result in proinflammatory microglial polarization and ultimately trigger neuroinflammatory progression after ICH. Qinglongyi nanoparticle (QLY NP) treatment can suppress neuronal Ferroptosis, thereby inhibiting proinflammatory microglial polarization, reducing the hematoma volume in mice and ultimately facilitating neuronal survival and alleviating neuroinflammation in the context of ICH. Concurrently, QLY NP treatment resulted in minimal toxicity in mice. Overall, we showed that the QLY NPs could inhibit neuronal Ferroptosis, thereby alleviating neuroinflammation and ultimately leading to promising therapeutic outcomes in an ICH model. Hence, with further research, QLY NPs may be an efficacious treatment for ICH.

Keywords

ICH; Nanoparticles; Neuroinflammation; Neuronal ferroptosis; QLY.

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