2. Academic Validation
  3. TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism

TNF-α Promotes the Recovery of Dorsal Root Ganglion Neurons from Cisplatin-Induced Injury Through an NGF-Independent Mechanism

  • Curr Issues Mol Biol. 2025 Jun 24;47(7):482. doi: 10.3390/cimb47070482.
Yiling Wei 1,  Xianlin Xu 2,  Pan Wu 1,  Xiang Chen 1,  Qingmei Mo 1,  Ming Zhuo 1
Affiliations

Affiliations

  • 1 Medical School, Guizhou University, Guiyang 550000, China.
  • 2 Department of Biochemistry, School of Preclinical Medicine, Zunyi Medical University, Zunyi 563100, China.
PMID: 40728951 DOI: 10.3390/cimb47070482
Abstract

Nerve injury caused by chemotherapy drugs is a common side effect. How to reduce this kind of nerve injury and promote neuron recovery is of great significance. In this study, we found that tumor necrosis factor-α (TNF-α) promoted the recovery of dorsal root ganglion (DRG) neuron from cisplatin-induced injury. On DRG neurons cultured in vitro, we found that TNF-α promoted neurite regeneration after cisplatin injury. In addition, TNF-α accelerated the removal of DNA damage and promoted the regeneration of mitochondria on DRG neurons. Study of the mechanism showed that this effect of TNF-α was independent from the NGF signaling pathway and occurred mostly through the activation of TNFR2 receptors, together with nucleus translocation of p65 and upregulation of NF-κB expression. This study provides a new theoretical basis and therapeutic strategy for the treatment of nerve injury caused by chemotherapy drugs.

Keywords

CIPN; DNA damage; DRG; TNFR2; mitochondrial damage; nerve growth factor; neurite regeneration; tumor necrosis factor α.

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