2. Academic Validation
  3. Tetrahydroxy Diboron-Initiated Injectable Hydrogel with Integrated Rapid Gelation, Fatigue Resistance, Bioadhesion, Antibacterial Activity, ROS Scavenging, and Osteoinduction for Periodontitis Treatment

Tetrahydroxy Diboron-Initiated Injectable Hydrogel with Integrated Rapid Gelation, Fatigue Resistance, Bioadhesion, Antibacterial Activity, ROS Scavenging, and Osteoinduction for Periodontitis Treatment

  • Biomacromolecules. 2025 Oct 13;26(10):6927-6939. doi: 10.1021/acs.biomac.5c01232.
Peiyue Pan 1,  Qianqian Liang 2,  Jia Xu 3,  Chao Huang 1,  Jia Shi 1,  Lijuan Zhao 2,  Tian Tang 1,  Jinrong Wu 4,  Yi Wang 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
  • 2 College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, Sichuan 610068, China.
  • 3 Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong 510280, China.
  • 4 College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials (Sichuan University), Sichuan University, Chengdu, Sichuan 610065, China.
PMID: 40985928 DOI: 10.1021/acs.biomac.5c01232
Abstract

Injectable hydrogels are promising for periodontitis treatment, yet achieving rapid gelation, mechanical strength, and multifunctionality under physiological conditions is challenging. Here, we report a tetrahydroxy diboron (THDB)-initiated hydrogel comprising N,N-dimethylacrylamide (DMAA), chlorhexidine, and carboxymethyl chitosan (CMCS), which gels within 2 min without deoxygenation. THDB reacts with vinyl monomers and oxygen to overcome inhibition while undergoing structural evolution to form functional domains. The hydrogel features: (1) dynamic hydrogen bonding and B-O/N coordination for enhanced strength; (2) THDB-CMCS interaction for strong bioadhesion; (3) boronic acid-induced acidity for Antibacterial activity against P. gingivalis, S. mutans, S. aureus, and E. coli; and (4) Reactive Oxygen Species (ROS) scavenging via residual B-B bonds to promote osteogenesis. In vivo, it accelerates alveolar bone regeneration in a rat periodontitis model. This one-step injectable platform integrates gelation, reinforcement, adhesion, Antibacterial, and antioxidative properties, offering strong therapeutic potential for periodontitis and related inflammatory diseases.

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