2. Academic Validation
  3. Oral VV261 administration protects mice from lethal Crimean-Congo hemorrhagic fever virus challenge

Oral VV261 administration protects mice from lethal Crimean-Congo hemorrhagic fever virus challenge

  • J Virol. 2025 Dec 23;99(12):e0158325. doi: 10.1128/jvi.01583-25.
Xi Wang # 1,  Huan Xu # 1 2,  Liushuai Li 1,  Fan Wu 1,  Jiang Li 1,  Jingshan Shen 3,  Gengfu Xiao 1,  Wei Zheng 4,  Leike Zhang 1,  Zhihong Hu 1,  Manli Wang 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
  • 2 Department of Pediatrics, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China.
  • 3 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • 4 Vigonvita Shanghai Co., Ltd, Shanghai, China.
  • # Contributed equally.
PMID: 41288381 DOI: 10.1128/jvi.01583-25
Keywords

Crimean-Congo hemorrhagic fever virus; VV261; nucleoside analog; oral administration.

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