1. Academic Validation
  2. VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses

VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses

  • J Neuroinflammation. 2025 Dec 5;23(1):11. doi: 10.1186/s12974-025-03645-7.
Xianbin Wang # 1 2 Rong Hu # 1 3 Kezhu Chen 1 3 Keke He 1 3 Yuandi Li 1 3 Jie Gao 3 Yishen Tian 3 Guangshi Du 3 Zuli Wang 4 Youbo Zhao 5 6 Laijun Lai 7 Min Su 8 9 10
Affiliations

Affiliations

  • 1 Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 2 Department of Rehabilitation Medicine, Affiliated Hospital of Guizhou Medical University, No. 28, Guiyi Street, Yunyan District, Guiyang, Guizhou, 550001, China.
  • 3 Department of Histology and Embryology, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 4 Guizhou Province Key Laboratory of Regenerative Medicine, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 5 National Joint Local Engineering Laboratory for Cell Engineering and Biomedicine Technique, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 6 Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences), Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 7 Department of Allied Health Sciences, University of Connecticut, 1390 Storrs Road, Storrs, CT, 06269, USA.
  • 8 Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China. [email protected].
  • 9 Department of Histology and Embryology, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China. [email protected].
  • 10 Key Laboratory for Research on Autoimmune Diseases of Higher Education schools in Guizhou Province, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China. [email protected].
  • # Contributed equally.
Keywords

B7 superfamily; Co-inhibitory molecules; Nectin-2; T cells; VSIG2.

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