2. Academic Validation
  3. Progress and Future Perspectives of Treg Cell Therapy

Progress and Future Perspectives of Treg Cell Therapy

  • Front Biosci (Landmark Ed). 2025 Nov 27;30(11):41250. doi: 10.31083/FBL41250.
Kehua Fang 1,  Jinbao Zong 2,  Xiaotian Chang 3 4
Affiliations

Affiliations

  • 1 Clinical Laboratory, The Affiliated Hospital of Qingdao University, 266000 Qingdao, Shandong, China.
  • 2 Clinical Laboratory and Qingdao Key Laboratory of Immunodiagnosis, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), 266000 Qingdao, Shandong, China.
  • 3 Medical Research Center, The Affiliated Hospital of Qingdao University, 266000 Qingdao, Shandong, China.
  • 4 Medical School, Qingdao Huanghai University, 266000 Qingdao, Shandong, China.
PMID: 41351401 DOI: 10.31083/FBL41250
Abstract

The important immunoregulatory roles of regulatory T cells (Tregs) include fostering tolerance to infections, controlling immune surveillance, and curtailing autoimmunity. Years of research have not only generated abundant knowledge in the field of Treg biology but also enabled the initial application of Tregs in cell therapy. However, most data in this field are obtained from laboratory Animals and in vitro experiments. This review provides an updated summary and the latest understanding of Treg-targeting cell therapy. We introduce the unique traits of Tregs, review animal experiments and clinical trials on Treg injections, discuss limitations of Treg applications, and consider future perspectives on Treg-based therapies. Overall, the safety and potential efficacy of Tregs will broaden the scope of cell-based treatments.

Keywords

Tregs (regulatory T cells); cell therapy; immunodeficiency; immunoregulation; immunotherapy.

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