2. Academic Validation
  3. Immunoregulatory Bioinspired Hydrogel from Decellularized Amnion for Infected Wound Healing

Immunoregulatory Bioinspired Hydrogel from Decellularized Amnion for Infected Wound Healing

  • ACS Appl Mater Interfaces. 2026 Jan 14;18(1):1032-1047. doi: 10.1021/acsami.5c24924.
Chunbiao Wu 1 2,  Juelan Ye 1 2,  Zhou Zhang 3,  Qiang Zhang 4,  Jiafeng Hou 1,  Haocheng Zhu 2,  Mingyan Liu 5,  Hao Wang 1,  Jianru Xiao 1 2
Affiliations

Affiliations

  • 1 Institute of Orthopaedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
  • 2 Deparrtment of Orthopaedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
  • 3 Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Yangpu District, Shanghai 200438, China.
  • 4 Department of Plastic Surgery, The Affiliated Hospital of Yangzhou University,Yangzhou University, 368 Hanjiang Middle Road, Yangzhou 225009, China.
  • 5 Medical Genetic Center, Yangzhou Maternal and Child Health Care Hospital, The Affiliated Hospital of Yangzhou University Medical College, Yangzhou, Jiangsu 225000, China.
PMID: 41480838 DOI: 10.1021/acsami.5c24924
Abstract

Infectious wounds remain a formidable clinical challenge due to persistent Bacterial colonization, uncontrolled inflammation, and impaired tissue regeneration. To address these issues, we developed a multifunctional immunoregulatory hydrogel by integrating curcumin (Cur) loaded polydopamine (PDA)-coated zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (Cur/ZIF/PDA) into a photo-cross-linkable hydrogel matrix derived from decellularized human amniotic membrane (dECMMA). This bioinspired hydrogel (dECMMA/ZIF/PDA) exhibited enhanced photothermal Antibacterial activity, controlled drug release, and excellent biocompatibility. In vitro and in vivo studies demonstrated that the hydrogel not only efficiently eradicated bacteria but also promoted macrophage polarization toward an anti-inflammatory M2 phenotype, upregulated angiogenesis-related gene expression, and accelerated wound re-epithelialization and Collagen remodeling. Notably, the synergistic action of photothermal therapy and immunomodulation significantly improved healing outcomes in a Staphylococcus aureus (S. aureus) infected wound model. This study presents a promising strategy for chronic wound management by leveraging naturally derived extracellular matrix components and multifunctional nanocarriers to orchestrate immune microenvironment remodeling and tissue regeneration.

Keywords

Infectious wounds; bioinspired hydrogel; decellularized amniotic membrane; immunomodulation; photothermal therapy.

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