2. Academic Validation
  3. A 3D-Printed Composite Hydrogel Engineered with a Coordination-Reprogrammed Nanozyme for Synergistic Chemo-Physical Bone Therapy

A 3D-Printed Composite Hydrogel Engineered with a Coordination-Reprogrammed Nanozyme for Synergistic Chemo-Physical Bone Therapy

  • ACS Appl Mater Interfaces. 2026 Feb 25;18(7):11117-11133. doi: 10.1021/acsami.5c25694.
Shi Qiu 1 2,  Zhengjiang Xu 1 2,  Xiaona Ning 3,  Junkang Chen 1,  Yuan Zhang 1,  Ben Wu 1,  Xiaoyi Ma 1,  Changshun Ruan 1,  Fuwei Liu 4,  Yunpeng Bai 5,  Guocheng Wang 1 2 6
Affiliations

Affiliations

  • 1 Research Center for Human Tissues & Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • 2 University of Chinese Academy of Sciences, Beijing 100049, China.
  • 3 Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
  • 4 State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
  • 5 Department of Prosthodontics and Implantology, Shenzhen University Affiliated Shenzhen Stomatology Hospital, Shenzhen 518001, China.
  • 6 State Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
PMID: 41680112 DOI: 10.1021/acsami.5c25694
Abstract

Impaired diabetic bone regeneration, driven by excessive Reactive Oxygen Species (ROS) and dysregulated inflammation, is a major clinical challenge. Herein, we engineered a hierarchical 2-dimethylimidazole (Hmim)/polydopamine (PDA) composite and integrated it into a 3D-printed hydrogel scaffold for chemo-physical therapeutic relay. Fabricated via in situ polymerization, the composite reconfigures PDA's coordination environment, optimizes Co2+/Co3+ modulation, boosts Co loading, and exhibits remarkably enhanced superoxide dismutase (SOD)-like activity. The 3D-printed hydrogel enables localized sustained release of the composite, which scavenges ROS and induces M2 macrophage polarization to correct the pathological microenvironment. Upon NIR irradiation, PDA's photothermal effect further promotes osteogenesis and vascularization, forming a "chemical regulation-physical stimulation" relay.This work develops a composite-based 3D-printed platform and validates the chemo-physical strategy for diabetic bone regeneration.

Keywords

3D printing; ccomposite hydrogels; diabetic bone regeneration; immunomodulation; nanozymes.

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