miR-1180-5p as a potential biomarker for the standard diagnosis of gestational diabetes and its correlation with pregnancy outcomes

BACKGROUND: Gestational diabetes mellitus (GDM) poses a serious threat to maternal and fetal health. OBJECTIVE: To investigate the clinical significance and molecular mechanisms of miR-1180-5p in GDM and evaluate its potential as a diagnostic and prognostic biomarker. METHODS: It includes GDM patients and healthy pregnant women in this research. The diagnostic value of miR-1180-5p expression levels for GDM was estimated using ROC curves. Correlation analysis was used to estimate the relationship between miR-1180-5p expression levels and GDM indicators. Multivariate logistic regression analysis was performed to estimate the risks of poor pregnancy outcomes in patients with GDM. RESULTS: miR-1180-5p expression was significantly elevated in GDM patients, and the ROC curve indicated it had moderate diagnostic efficacy. Its expression was closely linked to fasting blood glucose and HOMA-IR. The high-expression group showed increased neonatal and placental weights and a higher incidence of adverse pregnancy outcomes. It was confirmed that it can target and combine to the TXLNA to regulate expression. CONCLUSION: miR-1180-5p is a potential diagnostic and prognostic biomarker for GDM. It participates in the pathological process of GDM through its target regulation mechanism, thus providing new evidence for clinical management.

Gestational diabetes mellitus; Pregnancy outcomes; miR-1180-5p.