2. Academic Validation
  3. Implantable piezocatalytic enzyme hydrogel re-engineers metabolic reprogramming for ischemic stroke therapy

Implantable piezocatalytic enzyme hydrogel re-engineers metabolic reprogramming for ischemic stroke therapy

  • J Control Release. 2026 Jun 10:394:114866. doi: 10.1016/j.jconrel.2026.114866.
Ruizhen Lv 1,  Yong Liu 2,  Yao Qi 1,  Xing Huang 1,  Jiawei Liu 3,  Jia Liang 4,  Yijie Shi 5,  Liang Zhao 6
Affiliations

Affiliations

  • 1 School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China.
  • 2 School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, PR China.
  • 3 Institution of Life Science, Jinzhou Medical University, Jinzhou 121000, PR China.
  • 4 Institution of Life Science, Jinzhou Medical University, Jinzhou 121000, PR China; Liaoning Provincial Key Laboratory of Neurodegenerative Diseases, Jinzhou Medical University, Jinzhou 121000, PR China; Collaborative Innovation Center for Age-related Disease, Jinzhou Medical University, Jinzhou 121000, PR China. Electronic address: [email protected].
  • 5 School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China; Collaborative Innovation Center for Age-related Disease, Jinzhou Medical University, Jinzhou 121000, PR China. Electronic address: [email protected].
  • 6 School of Pharmacy, Jinzhou Medical University, Jinzhou 121000, PR China; Liaoning Provincial Key Laboratory of Neurodegenerative Diseases, Jinzhou Medical University, Jinzhou 121000, PR China; Collaborative Innovation Center for Age-related Disease, Jinzhou Medical University, Jinzhou 121000, PR China. Electronic address: [email protected].
PMID: 41895532 DOI: 10.1016/j.jconrel.2026.114866
Abstract

Internal wireless electric stimulation (ES) based on piezoelectric Materials with ultrasound (US) stimulation has emerged as a promising noninvasive strategy of tissue regeneration. However, due to poor electric field generation and their inherent ability to generate Reactive Oxygen Species (ROS), piezoelectric Materials have few been explored for the treatment of ROS related ischemic stroke (IS). Based on these properties, we design an intracerebrally injectable thermosensitive hydrogel (US+BCGTs@TSG) utilizing US-activated piezoelectric heterojunction known as BCGTs composed of barium titanate (BaTiO3, BTO), cerium oxide (CeO2), and graphene quantum dots (GQDs) for treating IS. Compared with conventional drug intravenous administration, in situ intracerebral injection of thermosensitive US+BCGTs@TSG can rapidly form a gel-like structure at body temperature, allowing for the direct delivery of therapeutic agents to the infarcted area. Following US, BCGTs target and repair mitochondria, inhibiting the occurrence of anaerobic metabolism. The combination of CeO2 and GQDs facilitates electron transfer while also suppresses the generation of ROS from the piezoelectric Materials. As a result, US+BCGTs@TSG contributes to a synergistic neuroprotective therapy and significantly reduces IS mediated neurodysfunction and depressive disorder.

Keywords

Heterojunction; Ischemic stroke; Piezoelectric material; Reactive oxygen species; Ultrasound.

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