2. Academic Validation
  3. Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica

Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica

  • J Nat Prod. 1995 Jul;58(7):1032-8. doi: 10.1021/np50121a007.
S Ohnishi 1,  N Fukamiya,  M Okano,  K Tagahara,  K H Lee
Affiliations

Affiliation

  • 1 Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan.
PMID: 7561896 DOI: 10.1021/np50121a007
Abstract

Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian Cancer cell lines with log GI50 values in the range of -4.14 to -5.72.

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