2. Academic Validation
  3. The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells

  • J Nat Prod. 1995 Apr;58(4):527-31. doi: 10.1021/np50118a007.
H Chen 1,  S F Yeh,  G T Ong,  S H Wu,  C M Sun,  C K Chou
Affiliations

Affiliation

  • 1 Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.
PMID: 7623030 DOI: 10.1021/np50118a007
Abstract

We have examined the Antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.

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