2. Academic Validation
  3. Methyl ethers of podophyllotoxin-related cyclolignans

Methyl ethers of podophyllotoxin-related cyclolignans

  • J Nat Prod. 1995 Jun;58(6):870-7. doi: 10.1021/np50120a008.
J M Miguel del Corral 1,  M Gordaliza,  M A Castro,  L J Morales,  J L Lopez,  A San Feliciano
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, Faculty of Pharmacy, University of Salamanca, Spain.
PMID: 7673931 DOI: 10.1021/np50120a008
Abstract

Methyl ethers of podophyllotoxin [1] and its epimers at positions 7 and 8' were obtained through the corresponding chlorinated or brominated derivatives at position 7. Additionally, the corresponding diol methyl ethers were obtained by reducing the lactone with LiAlH4. 7-O-Methylepipicropodophyllotoxin [12], 7-O-methylpicropodophyllotoxin [13], the diol methyl ethers 15-18 and the corresponding diacetates are described here for the first time. Most of the cyclolignans obtained were evaluated for their cytotoxic activity.

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