2. Academic Validation
  3. Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

  • Gene. 1995 Apr 3;155(2):261-5. doi: 10.1016/0378-1119(94)00842-g.
M Lopez 1,  F Eberlé,  M G Mattei,  J Gabert,  F Birg,  F Bardin,  C Maroc,  P Dubreuil
Affiliations

Affiliation

  • 1 INSERM U.119, Unité de Cancérologie et Thérapeutique Expérimentales, Marseille, France.
PMID: 7721102 DOI: 10.1016/0378-1119(94)00842-g
Abstract

The human poliovirus (PV) receptor (PVR) is a member of the immunoglobulin (Ig) superfamily with unknown cellular function. We have isolated a human PVR-related (PRR) cDNA. The deduced amino acid (aa) sequence of PRR showed, in the extracellular region, 51.7 and 54.3% similarity with human PVR and with the murine PVR homolog, respectively. The cDNA coding sequence is 1.6-kb long and encodes a deduced 57-kDa protein; this protein has a structural organization analogous to that of PVR, that is, one V- and two C-set Ig domains, with a conserved number of aa. Northern blot analysis indicated that a major 5.9-kb transcript is present in all normal human tissues tested. In situ hybridization showed that the PRR gene is located at bands q23-q24 of human chromosome 11.

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