2. Academic Validation
  3. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

  • Science. 1994 May 13;264(5161):965-8. doi: 10.1126/science.8178155.
K H Grabstein 1,  J Eisenman,  K Shanebeck,  C Rauch,  S Srinivasan,  V Fung,  C Beers,  J Richardson,  M A Schoenborn,  M Ahdieh
Affiliations

Affiliation

  • 1 Immunex Research and Development Corporation, Seattle, WA 98101.
PMID: 8178155 DOI: 10.1126/science.8178155
Abstract

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal Antibodies to the beta chain of the IL-2 Receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 Receptor.

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