2. Academic Validation
  3. Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines

Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines

  • J Med Chem. 1994 May 13;37(10):1465-70. doi: 10.1021/jm00036a012.
M E Wall 1,  M C Wani,  F Fullas,  J B Oswald,  D M Brown,  T Santisuk,  V Reutrakul,  A T McPhail,  N R Farnsworth,  J M Pezzuto
Affiliations

Affiliation

  • 1 Research Triangle Institute, Research Triangle Park, North Carolina 27709.
PMID: 8182705 DOI: 10.1021/jm00036a012
Abstract

Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.

Figures