2. Academic Validation
  3. Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties

Aquastatin A, an inhibitor of mammalian adenosine triphosphatases from Fusarium aquaeductuum. Taxonomy, fermentation, isolation, structure determination and biological properties

  • J Antibiot (Tokyo). 1993 Nov;46(11):1648-57. doi: 10.7164/antibiotics.46.1648.
K Hamano 1,  M Kinoshita-Okami,  K Minagawa,  H Haruyama,  T Kinoshita,  T Hosoya,  K Furuya,  K Kinoshita,  K Tabata,  A Hemmi, et al.
Affiliations

Affiliation

  • 1 Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
PMID: 8270486 DOI: 10.7164/antibiotics.46.1648
Abstract

A new inhibitor of mammalian adenosine triphosphatases, designated aquastatin A, has been isolated from a fungus identified as Fusarium aquaeductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na+/K(+)-ATPase with an IC50 value of 7.1 microM, and H+/K(+)-ATPase with an apparent IC50 value of 6.2 microM.

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