2. Academic Validation
  3. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties

UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties

  • J Antibiot (Tokyo). 1993 Jul;46(7):1089-94. doi: 10.7164/antibiotics.46.1089.
M Ueki 1,  K Ueno,  S Miyadoh,  K Abe,  K Shibata,  M Taniguchi,  S Oi
Affiliations

Affiliation

  • 1 Faculty of Science, Osaka City University, Japan.
PMID: 8360104 DOI: 10.7164/antibiotics.46.1089
Abstract

A new benzoxazole, UK-1, was isolated from the mycelial cake of an actinomycete strain 517-02. Based on morphological, cultural and physiological characteristics, strain 517-02 was seemed to be a close relative of Streptomyces morookaense. UK-1 showed potent cytotoxic activity against B16, HeLa and P388 cells and did not show any antimicrobial activity.

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