2. Academic Validation
  3. Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2

Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2

  • J Virol. 1993 Nov;67(11):6847-52. doi: 10.1128/JVI.67.11.6847-6852.1993.
J M Bergelson 1,  N St John,  S Kawaguchi,  M Chan,  H Stubdal,  J Modlin,  R W Finberg
Affiliations

Affiliation

  • 1 Laboratory of Infectious Disease, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
PMID: 8411387 DOI: 10.1128/JVI.67.11.6847-6852.1993
Abstract

Anti-VLA-2 Antibodies protected HeLa cells from Infection by echoviruses 1 and 8 but not from Infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for Infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.

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