2. Academic Validation
  3. Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells

Influence of the Gloeophyllum metabolite oosponol and some synthetic analogues on protein and RNA synthesis in target cells

  • Eur J Biochem. 1997 May 15;246(1):45-9. doi: 10.1111/j.1432-1033.1997.t01-2-00045.x.
J Sonnenbichler 1,  T Kovács
Affiliations

Affiliation

  • 1 Max-Planck-Institut für Biochemie, Martinsried, Germany.
PMID: 9210464 DOI: 10.1111/j.1432-1033.1997.t01-2-00045.x
Abstract

Oosponol [4-(hydroxyacetyl)-8-hydroxy-1H-2-benzopyran-1-one], a toxic metabolite of the basidiomycete Gloeophyllum abietinum, and some synthetic analogues were studied to clarify the molecular basis of their fungicidal, bactericidal, and phytotoxic effects. The Antibiotic activity was due to a strong inhibition of RNA and protein synthesis in target cells.

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