2. Academic Validation
  3. A novel long-acting VIP analog in the guinea pig trachea in vitro

A novel long-acting VIP analog in the guinea pig trachea in vitro

  • Peptides. 1998;19(3):593-7. doi: 10.1016/s0196-9781(97)00457-9.
S Yoshihara 1,  A Lindén,  K Kashimoto,  S Watanabe
Affiliations

Affiliation

  • 1 First Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan.
PMID: 9533650 DOI: 10.1016/s0196-9781(97)00457-9
Abstract

The relaxant effect of a novel VIP analog, [Arg15,20,21Leu17]-VIP-Gly-Lys-Arg-NH2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analog caused significantly and concentration-dependent relaxation similarly to the original VIP. In contrast to the original VIP, the VIP analog demonstrated a slow onset and offset of action, with more than 90% of its maximum relaxation remaining 6 h after administration. Peptidase inhibition by captopril and phosphoramidon increased the relaxant effect and duration of action for original VIP but not for the VIP analog.

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