2. Academic Validation
  3. Bioactive kaurane diterpenoids from Annona glabra

Bioactive kaurane diterpenoids from Annona glabra

  • J Nat Prod. 1998 Apr;61(4):437-9. doi: 10.1021/np970497z.
F R Chang 1,  P Y Yang,  J Y Lin,  K H Lee,  Y C Wu
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, Kaosiung Medical College, Taiwan, Republic of China.
PMID: 9584397 DOI: 10.1021/np970497z
Abstract

Phytochemical analysis of the fruits of Annona glabra yielded two new kaurane Diterpenoids, annoglabasin A (methyl-16 beta-acetoxy-19-al-ent-kauran-17-oate)(1) and annoglabasin B (16 alpha-hydro-19-acetoxy-ent-kauran-17-oic acid)(2), along with 11 known kaurane derivatives (3-13). The structures of the new compounds were established by spectral and chemical evidence. Among these, methyl-16 alpha-hydro-19-al-ent-kauran-17-oate (11) exhibited mild activity against HIV replication in H9 lymphocyte cells, and 16 alpha-17-dihydroxy-ent-kauran-19-oic acid (4) showed significant inhibition of HIV-reverse transcriptase.

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