2. Academic Validation
  3. Synthesis of (+/-)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage

Synthesis of (+/-)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage

  • J Nat Prod. 1998 May;61(5):609-13. doi: 10.1021/np970555g.
T Masuda 1,  H Matsumura,  Y Oyama,  Y Takeda,  A Jitoe,  A Kida,  K Hidaka
Affiliations

Affiliation

  • 1 Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima 770, Japan. [email protected]
PMID: 9599258 DOI: 10.1021/np970555g
Abstract

A chemical synthesis of cassumunins A (1) and B (2), natural curcuminoid Antioxidants, was developed. The synthesis was started from o-vanillin and after nine reaction steps resulted in 20% and 26% overall yields of 1 and 2, respectively. The synthetic cassumunins showed stronger protective activity than curcumin against oxidative cell death induced by hydrogen peroxide in a rat thymocyte system.

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