2. Academic Validation
  3. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis

Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis

  • J Nat Prod. 1998 Nov;61(11):1413-5. doi: 10.1021/np980163p.
T Nishioka 1,  J Kawabata,  Y Aoyama
Affiliations

Affiliation

  • 1 Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Kita-ku, Sapporo 060-8589, Japan.
PMID: 9834167 DOI: 10.1021/np980163p
Abstract

Methanol extracts of Scutellaria baicalensis, Rheum officinale, and Paeonia suffruticosa showed potent inhibitory activity against rat intestinal sucrase. The active principles were identified as baicalein from the first and methyl gallate from the last two Plants. In addition to its activity against the rat enzyme, baicalein also inhibited human intestinal sucrase expressed in Caco-2 cells.

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