2. Academic Validation
  3. Synthesis of imidazo[1,2-a]pyridines as antiviral agents

Synthesis of imidazo[1,2-a]pyridines as antiviral agents

  • J Med Chem. 1998 Dec 3;41(25):5108-12. doi: 10.1021/jm981051y.
A Gueiffier 1,  S Mavel,  M Lhassani,  A Elhakmaoui,  R Snoeck,  G Andrei,  O Chavignon,  J C Teulade,  M Witvrouw,  J Balzarini,  E De Clercq,  J P Chapat
Affiliations

Affiliation

  • 1 Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université de Tours, 31 Avenue Monge, 37200 Tours, France.
PMID: 9836626 DOI: 10.1021/jm981051y
Abstract

The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their Antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

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